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5,731+ REVIEWS
Restore Healthy Blood Flow, Oxygen Delivery, and Natural Energy... With Nitric Oxide Support That Actually Works
A synergistic blend of 6 ingredients (including patented French ViNitrox™ fruit stem cells) proven to optimize blood flow, increase oxygen delivery, and restore natural energy. Without L-Arginine side effects. Without synthetic stimulants. 100% natural, sugar-free.
  • Increase your energy levels naturally without stimulants.
  • Boost circulation and increase warmth to hands and feet
  • Recommended by cardiologists for optimal cardiovascular health.
  • Supports healthy blood pressure
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90-day money back
We’re so confident OxySpark will help you, we’re giving you 90 full days to try it out.
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Order any of our multi-bottle specials today and we will cover the shipping and handling fees inside the U.S.
High quality guaranteed
OxySpark is manufactured in an FDA-registered facility that is also cGMP certified.
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Why Thousands of People Are Switching To OxySpark
If you struggle with fatigue, brain fog, cold hands and feet, or high blood pressure…OxySpark could be exactly what your body’s been missing.
Most circulation and nitric oxide supplements rely on L-Arginine, a synthetic amino acid that only boosts blood flow for a few hours, but it can cause dangerous side effects, including heart issues and digestive problems.
That’s why more and more people over 50 — along with athletes and health-conscious adults — are ditching arginine-based supplements and turning to OxySpark instead.
Backed by Nobel Prize-winning research, OxySpark uses ViNitrox™️, a natural blend of apple and grape polyphenols that are clinically proven to:
  • Boost circulation 50%
  • Safely increase nitric oxide production by 24%
  • Increase energy levels to combat fatigue
  • Enhance exercise performance and recovery ​
  • Reduce inflammation by 50%
50%
Boost circulation
24%
Increase nitric oxide production
50%
Reduce inflammation
100%
Natural, science-backed ingredients.
What Happens After You Start Taking OxySpark
Experience noticeable improvements in your energy, mental clarity, and blood flow, all without L-Arginine or risky stimulants.
Day 10
Initiate Repair
ViNitrox™ and fruit stem cell polyphenols begin restoring your body’s nitric oxide production, setting the stage for better blood flow and cellular health.
Day 30
Blood Starts Flowing Freely
You’re likely to begin noticing reduced brain fog, more energy, warmer hands and feet, and less mid-day fatigue as your cells receive more oxygen and nutrients.
Day 90
Revitalize from the Inside Out
Daily use helps you maintain healthy blood pressure, energy, and mental sharpness by naturally supporting your cardiovascular system.
5,731+ REVIEWS
What People Are Saying About OxySpark…
SwaNee
It helps this old man
I am a soon to be 78 year old male. My family has a history of heart disease. However I hit the gym three times a week and do a lot of weight lifting and cardio. I am taking Oxyspark to help keep my arteries clear and my blood pressure in a healthy range. My results are encouraging, my energy is good and blood pressure is 120/78. I recommend this product!
  • Verified Customer
Roberto Villafane
Love Oxyspark 
Love Oxyspark.. I feel more energetic after being a long time user of Oxyspark.... You guys have me as a costumer for life. Thanks
  • Verified Customer
MACY BOWDEN
WORKS REALLY GOOD
WORKS REALLY GOOD, LOVE THE ENERGY AND NOT DROUSEY IN AFTERNOONS. AND EVAN SLEEP BETTER.
  • Verified Customer
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Clinically Studied Ingredients

What's Inside OxySpark™

A powerful blend of clinically studied ingredients designed to improve circulation, boost nitric oxide, and support full-body energy — without stimulants.

Vinitrox™

Patented

A patented blend of grape and apple polyphenols used in clinical trials to restore vascular function and support energy naturally.

  • Boost nitric oxide by 24%
  • Improve blood flow by 50%
  • Reduce inflammation by 50%
  • Neutralize free radicals during nitric oxide production

L-Citrulline

Amino Acid

A naturally occurring amino acid that works with Vinitrox™ to safely increase nitric oxide levels without the harsh side effects of L-Arginine pills.

  • Naturally raise L-Arginine levels in the body
  • Promote stronger vasodilation and blood flow
  • Enhance oxygen delivery to muscles and brain

Beet Root Powder

Superfood

Provides an additional nitrate pathway to further boost nitric oxide levels and support cardiovascular health.

  • Reinforce Vinitrox™ effects on blood vessel health
  • Support endurance and recovery
  • Popular among athletes for circulation and stamina

AstraGin®

Patented

A patented extract from astragalus and Panax notoginseng that enhances nutrient absorption across the board.

  • Increase L-Citrulline absorption by 45%
  • Help the body absorb key amino acids faster
  • Maximize nitric oxide production efficiency

CoQ10

Antioxidant

A heart-healthy antioxidant that fuels energy production at the cellular level for sustained performance.

  • Decrease oxidative stress and improve mitochondrial function
  • Promote peak cardiac performance
  • Reduce free radical damage linked to fatigue

Enzogenol®

Patented

A natural extract from New Zealand pine bark with powerful anti-inflammatory effects for whole-body health.

  • Reduce LDL cholesterol and systolic blood pressure
  • Support healthy blood circulation
  • Reduce risk of age-related eyesight deterioration
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OxySpark's Proprietary All-Natural Ingredients In A Great-Tasting Grape Flavor
OxySpark combines a proprietary blend of natural, non-GMO, gluten-free ingredients with ViNitrox™, a clinically studied compound proven to enhance nitric oxide production and vasodilation more effectively than typical arginine-based supplements.
While most nitric oxide boosters taste bitter or synthetic, OxySpark delivers a naturally sweet grape flavor you’ll actually enjoy, no choking it down, no aftertaste.
Just mix one scoop with 8 oz. of water or milk, and you’ll soon start feeling the refreshing, energizing, and circulation-boosting effects of a nitric oxide formula that’s as clean as it is effective.
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WARNING: If your blood flow supplement contains L-Arginine, you must stop taking it now.
The Problem with L-Arginine
Published study on L-Arginine and nitric oxide
Published Research
Biochemical & Biophysical Research Communications

Most blood flow supplements rely on high doses of L-Arginine.

Studies show L-Arginine only improves blood flow by an average of 1.8% to 10% — and the effect fades within hours.

L-Arginine is an amino acid often used in generic nitric oxide supplements to temporarily dilate blood vessels. But the results are usually short-lived and often come with significant side effects, especially in older adults.

Known Side Effects
Can cause bloating, diarrhea, and stomach cramps
Linked to reactivation of viruses like herpes in sensitive users
Often requires high doses (7,000mg+) for minimal effect
May stress the kidneys and liver with long-term use
Not well tolerated in people over 40 due to declining enzyme activity
Worse: Recent studies show L-Arginine's effectiveness plummets as you age, making it a risky and unreliable long-term solution.
The Smarter Alternative

OxySpark works without L-Arginine.

It contains clinically studied, natural ingredients proven to boost nitric oxide, improve heart health, and increase circulation.

24%
Nitric Oxide Boost
50%
Better Circulation
0
Stimulants
  • Clinically studied, plant-based formula
  • No harsh side effects or high-dose requirements
  • Improves energy, heart, and brain health naturally
  • Effective regardless of age or enzyme activity
A smarter, plant-based formula thousands of people your age are already using to improve energy, heart, and brain health.
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Exactly What OxySpark Gives You
Backed by Nobel Prize-winning science, proven by real people.
Sharpen your Memory & Mental Clarity
Nitric oxide boosts blood flow to the brain, helping you stay focused, think clearly, and reduce brain fog without risky stimulants or synthetic ingredients.
Support Better Circulation
Nitric oxide boosts blood flow to the brain, helping you stay focused, think clearly, and reduce brain fog without risky stimulants or synthetic ingredients.
Sharpen your Memory & Mental Clarity
Nitric oxide boosts blood flow to the brain, helping you stay focused, think clearly, and reduce brain fog without risky stimulants or synthetic ingredients.
Reignite closeness With Your Partner
Research shows that improving nitric oxide levels supports healthy performance in bed, helping you feel confident and connected again naturally and safely.
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Natural Way To Improve Your Focus, Increase Energy & Support Heart Health Without L-Arginine
Unlike most nitric oxide boosters that rely on high doses of L-Arginine, OxySpark uses a clinically studied, low-dose ViNitrox™ formula that works better and faster, naturally.
Boosts Circulation & Heart Health
OxySpark helps your body produce more nitric oxide, a critical molecule that relaxes and widens blood vessels. Better circulation means better performance, endurance, and cardiovascular support.
  • Promotes vascular flexibility for easier blood flow and less resistance.
  • Supports endothelial function, the inner lining of blood vessels that regulates pressure.
  • Aids nutrient delivery to vital organs like your brain, heart, and muscles.
Energizes Without Stimulants
Unlike caffeine-based energy products that spike and crash, OxySpark provides clean, sustained energy. By naturally improving circulation and oxygenation, your body feels more alert, vital, and energized all day long without the jitters or crashes.
  • Increases cellular oxygen uptake for better endurance at the source.
  • Recharges mitochondrial efficiency, your body’s natural energy factories.
  • Reduces oxidative stress, which can drain your energy quickly.
Supports Mental Clarity & Focus
OxySpark sharpens mental performance by improving cerebral circulation, allowing you to think clearly, stay focused, and maintain mental stamina, even on demanding days.
  • Supports neurotransmitter function, helping messages travel faster in your brain.
  • Combats brain fog and mental fatigue linked to poor blood flow.
  • Improves blood flow to the brain, enhancing mental clarity.
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Two Futures
Imagine what changes
  • Your hands are warm when you reach for your morning coffee. You make it through the afternoon without hitting a wall.
  • Your thinking is clear at 4 PM, not just at 9 AM. You say yes to the hike, the grandkids, the dinner plans... not because you're pushing through, but because you actually have the energy.
  • You feel like yourself again. Not younger. Just... capable. Present. Not managing your limits but living past them.
Conventional Pain Relief Methods
  • The cold hands don't warm up on their own. The afternoon wall doesn't retreat. The fog doesn't lift.
  • And each year, the list of things you've quietly stopped doing gets a little longer. The stairs you avoid. The invitations you decline. The grandkids you watch from the bench instead of the yard.
  • And the hardest part isn't the bench. It's the moment you realize they've stopped asking you to join in.
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Clinical Studies Validate The Power Of OxySpark
OxySpark is supported by both clinical research and the real-world success stories of thousands of users.
Cell Revitalization Breakthrough
When the Bio Seare team first tested their ViNitrox™ formula, they were amazed by the results, needing three tests to confirm their findings. ViNitrox™ transforms your body into a nitric oxide-producing powerhouse by activating eNOS (endothelial nitric oxide synthase), your body's nitric oxide factory.1
In a lab study, ViNitrox™ boosted eNOS activation by 43% and increased nitric oxide production by 24%, helping cells function like they did years ago.1 This means ViNitrox™ not only enhances circulation but also restores your body's natural nitric oxide production.
Blood Flow Restoration
The researchers also discovered something even more important:
  • In a controlled laboratory study, they compared ViNitrox™ to leucocyanidol - a synthetic chemical specifically designed by pharmaceutical companies to dilate blood vessels.1
  • ViNitrox™ performed almost as well as the lab-made drug.
  • The blood vessels dilated by an incredible 50%.1
Here's the amazing part: ViNitrox™ works naturally without the side effects of pharmaceuticals. In comparison, L-arginine only dilates blood vessels by 1.8% to 10%, even at high doses of 7,000mg.2 This makes ViNitrox™ 5 to 25 times more effective than L-arginine.
Age-Fighting Inflammation Reduction
Here's where it gets interesting. Researchers aimed to understand why ViNitrox™ outperformed other supplements. They conducted a clinical trial with 34 individuals suffering from metabolic syndrome, each taking 500mg of ViNitrox™ daily for 28 days, the same amount that is in OxySpark and OxyBoost.
They found that ViNitrox™ reduced harmful inflammation by 50%,3 which is crucial because high inflammation damages the cells that produce nitric oxide. Unlike other blood flow supplements that can worsen inflammation, ViNitrox™ protects endothelial cells and keeps nitric oxide production steady, making it more effective over time.
Human Performance Enhancement
Dr. Louis Ignarro, Nobel Prize winner, says:
"I am convinced that nitric oxide can age-proof your cardiovascular system, keeping it much fitter than your chronological age would indicate."
ViNitrox™ enhances your body's nitric oxide production safely. In trials, users experienced:
  • 9.7% boost in endurance 2
  • 12.8% better effort tolerance 2
  • 16.2% improved recovery 2
These gains were from just one dose—imagine daily use!
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How OxySpark Compares With Other Supplements On The Market

OxySpark

Hydro
Soothe

listing_heading		Generic Supplements
Boosts nitric oxidecheck_marknot_check
Clinically proven resultscheck_marknot_check
Doesn’t contain harmful L-Arginine check_markcheck_mark
Improves blood flowcheck_marknot_check
Supports cardiovascular health check_marknot_check
Fast-actingcheck_markcheck_mark
Boosts energycheck_marknot_check
Fights inflammationcheck_marknot_check
Powerful antioxidantcheck_marknot_check
Doesn’t damage Nitric Oxide-producing cells check_marknot_check
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What Changes Actually Look Like (Day by Day)
So what should you expect? Not miracles overnight. Real changes, building over real time.
Days 1-7
First Signs
You notice your hands feel warmer... especially in the morning. That stubborn chill in your fingertips starts to ease. You might catch yourself making it to 2 PM without reaching for the coffee. It's subtle. But it's there.
Days 8-21
Building Momentum
The afternoon wall moves. Instead of crashing at 1 PM, you're making it through to dinner and still have something left. The fog lifts... names come faster, you lose your train of thought less often. You realize you've been saying "yes" to things you'd been quietly avoiding.
Days 22-45
Your New Baseline
This becomes your baseline. Steady energy. Warm hands and feet. Clearer thinking at 4 PM, not just at 9 AM. You don't feel 25 again... but you feel like yourself. The version of you that gets off the bench and into the yard with the grandkids. The version that doesn't plan the day around rest breaks.
Days 45-90+
Thriving Vitality
Peak restoration phase. Your body has rebuilt its nitric oxide production capacity. Circulation is optimized to the level your current health allows. Your body has fully adapted. Blood vessels stay open. Energy is steady. This is your new normal.
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Greg Ramola

"OxySpark has improved my blood flow which is evident when I exercise. My blood pressure has been lowered 10 to 15 points. My energy has increased as well as my overall sense of well-being. OxySpark does what it says it does and it tastes great!"
  • Yes, I recommend this product.
Product Overview
Harness the power of nature with OxySpark, our most advanced circulation and nitric-oxide–boosting drink powder. This delightful fruit-stem-cell blend ignites blood flow, sharpens mental clarity, and fuels full-body energy, without L-Arginine, stimulants, or synthetic additives. Based on Nobel Prize winning science, and trusted by over 29,000 satisfied customers.
Specs & Ingredients
ViNitrox™ (apple & grape stem cell polyphenols): Clinically proven to boost nitric oxide by ~24%, enhance blood flow up to 50%, reduce inflammation, and neutralize free radicals. Same dosage used in human clinical trials.
L-Citrulline: Converts into L-Arginine in the body to sustain nitric oxide production naturally, promoting vasodilation, endurance, and enhanced oxygen delivery.
Organic Beet Root Powder: A natural source of nitrates that further support nitric oxide synthesis and stamina, offering a “second-wind” boost.
AstraGin®: A patented extract (astragalus + ginseng) that improves the absorption of L-Citrulline by 167% in human studies, maximizing effectiveness.
CoQ10 & Enzogenol® (pine bark extract): Heart-protective antioxidants that support vascular function, reduce inflammation, and enhance overall cardiovascular support.
How to use them
Just mix one scoop with 8 oz. of water or milk, and you’ll soon start feeling the refreshing, energizing, and circulation-boosting effects of a nitric oxide formula that’s as clean as it is effective.
Timing: Best taken in the morning for all-day circulation, energy, and mental clarity.
Onset of Benefits: 
2–3 weeks: Noticeable improvements in energy, warmth in extremities, and cognitive sharpness.
1–3 months: Full benefits—including sustained vitality, improved stamina, clearer focus, and cardiovascular resilience.
Ingredient Facts
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Free U.S. Shipping on multi-bottle orders.
90-Day “Empty Bottle” Money-Back Guarantee—a full refund, no hassle, even if the bottle is empty.
5,731+ REVIEWS
OxySpark
Restore Healthy Blood Flow, Oxygen Delivery, and Natural Energy... With Nitric Oxide Support That Actually Works
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Jennifer L.
I been dealing with nerve pain for a while now and honestly didn’t think anything would help. But EMSense? Wow 🙌🏼 I use it every night now and my feet feel so much better. They’re not burning like before and I actually sleep through the night now.
  • Yes, I recommend this product.
Product Overview
Harness the power of nature with OxySpark, our most advanced circulation and nitric-oxide–boosting drink powder. This delightful fruit-stem-cell blend ignites blood flow, sharpens mental clarity, and fuels full-body energy, without L-Arginine, stimulants, or synthetic additives. Based on Nobel Prize winning science, and trusted by over 29,000 satisfied customers.
Specs & Ingredients
ViNitrox™ (apple & grape stem cell polyphenols): Clinically proven to boost nitric oxide by ~24%, enhance blood flow up to 50%, reduce inflammation, and neutralize free radicals. Same dosage used in human clinical trials.
L-Citrulline: Converts into L-Arginine in the body to sustain nitric oxide production naturally, promoting vasodilation, endurance, and enhanced oxygen delivery.
Organic Beet Root Powder: A natural source of nitrates that further support nitric oxide synthesis and stamina, offering a “second-wind” boost.
AstraGin®: A patented extract (astragalus + ginseng) that improves the absorption of L-Citrulline by 167% in human studies, maximizing effectiveness.
CoQ10 & Enzogenol® (pine bark extract): Heart-protective antioxidants that support vascular function, reduce inflammation, and enhance overall cardiovascular support.
How to use them
Just mix one scoop with 8 oz. of water or milk, and you’ll soon start feeling the refreshing, energizing, and circulation-boosting effects of a nitric oxide formula that’s as clean as it is effective.
Timing: Best taken in the morning for all-day circulation, energy, and mental clarity.
Onset of Benefits: 
2–3 weeks: Noticeable improvements in energy, warmth in extremities, and cognitive sharpness.
1–3 months: Full benefits—including sustained vitality, improved stamina, clearer focus, and cardiovascular resilience.
Ingredient Facts
Shipping & Risk-Free Guarantee
Free U.S. Shipping on multi-bottle orders.
90-Day “Empty Bottle” Money-Back Guarantee—a full refund, no hassle, even if the bottle is empty.
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Thousands Of Happy Users
4.9
1257 Reviews
Dr. Richard Krein, DC
Verified Buyer
A Healthcare Practitioner's Experience
"I now recommend OxySpark to my patients because it worked wonders for me. Thave a long standing history of heart disease in my family (my father died of heart attack at 58 yrs). When I turned 58, my blood pressure was through the roof (180/110). With OxySpark my blood pressure has normalized and I have lower cholesterol/triglyceride levels. Plus, OxySpark gives me tons more energy. OxySpark will change your life as it has mine - and you feel it happening."
Gary Coffman
Verified Buyer
Vast Improvements In My Circulation
"I used OxySpark about 3 years ago and stopped using it despite the improvements I noticed. Not sure why, had intentions of ordering again and never got it done until almost a month ago. I'm already seeing and feeling a vast improvements in my circulation and energy levels. I'm 70 years old and I won't be without this product again. There's no doubt it HELPS ME feel better."
John and Jayleen Bryan
Verified Buyer
More Energy at 86 and 87 Years Old
"My husband and I love OXYSPARK! I was having to get a deep breath all day long. I knew my cousin was taking OXYSPARK so I ask her about the product. She graciously gave me a container and I began taking it. Within a day or two my having to take a deep breath was gone. We also began having more energy! At 86 and 87 years old, we need all the help we can get!! Thank you, OXYSPARK!!"
Susan A.
Verified Buyer
Blood Pressure Dropped In 3 Weeks
"My husband and I both take Oxy Spark. I first bought it hoping it would help with his heart failure (keeping his blood pressure down). It works so well he doesn’t have to take one of his BP meds. Mine has never been in the “high range” but dropped down in the teens, after 3 weeks. My Dr said, “well, keep taking it!”
David Zeller
Verified Buyer
Back To Working Out 6 Days A Week
"As I've aged, my stamina has diminished and I also got a pacemaker put in because my heart was pausing up to 9 seconds when I sleep. I ordered OxySpark because I wanted to help my heart health. Now, with OxySpark, I'm very healthy now and able to do cardio and weight work outs 6 days a week without any heart issues. My heart is performing better than ever!! OxySpark is the best nitric oxide boosting product I've ever used. Nothing else comes even close!!"
90-Day Money-Back Guarantee
We put our money where our mouth is.
If you’re unhappy with OxySpark, you’re eligible for a 100% refund within 30 days.
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OxySpark Supplement Facts
Frequently Asked Questions
Got questions? We’ve got answers.
How long does it take to feel the effects of OxySpark™?
Most users begin to feel noticeable improvements in circulation, energy, and focus within 7–14 days. For optimal, long-lasting results, we recommend consistent daily use for at least 30 days.
What makes OxySpark different from other nitric oxide supplements?
While most blood flow supplements rely on outdated L-Arginine formulas, OxySpark skips synthetic aminos entirely. Instead, it uses ViNitrox — a clinically studied blend of apple and grape stem cell polyphenols that’s been shown to increase circulation by 50%, boost nitric oxide by 24%, and reduce inflammation naturally.
Is OxySpark safe for people with high blood pressure?
Yes — OxySpark is designed to support healthy blood pressure by improving vascular function and promoting smoother circulation. However, if you're currently taking medication or managing a medical condition, we always recommend consulting your healthcare provider first.
Will it make me feel jittery like caffeine?
Not at all. OxySpark contains zero stimulants. It works by increasing blood flow and oxygen delivery at the cellular level, helping your body feel naturally energized without any crash or weird feeling.
When is the best time to take OxySpark™?
Mix one scoop with 8 oz of water or your favorite drink once daily. Morning or early afternoon works best to support all-day circulation and energy.
Is there a money-back guarantee?
Absolutely. If you don’t feel a difference in energy, clarity, or circulation within 90 days, simply reach out, and we’ll refund your order. No questions asked.
Who should take OxySpark™?
OxySpark is ideal for adults looking to improve circulation, energy, memory, and cardiovascular health, especially those over 50 or anyone experiencing cold extremities, fatigue, or brain fog due to poor blood flow.
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5,731+ REVIEWS
What Are You Waiting For? Improve Your Circulation, Cognition & Energy In Just 30 Days.
If 30 days after taking OxySpark regularly, you don’t see any improvements in your energy, circulation, and overall well-being, just contact us, and we will send your money back. No questions asked.
  • Increase your energy levels naturally without stimulants.
  • Recommended by cardiologists for optimal cardiovascular health.
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Clinical Studies
OxySpark – a supplement you can actually trust. Backed by real science.
  1. Effect of ViNitrox™ on the activation of eNOs through the phosphorylation of “Serine 1177” from endothelial cells (HUVECs) as measured by flow cytometry (2010)
  2. Ex-Vivo laboratory study: ViNitrox™ stimulates the production of nitric oxide (NO) by vascular endothelium
  3. An acute dose of specific grape and apple polyphenols improves endurance performance: A randomized, crossover, double blind versus placebo controlled study
  4. Randomized, crossover, double blind, placebo controlled study of the effect a single dose of ViNitrox™ on performance upon effort and recovery in healthy volunteers
  5. Increase in fasting vascular endothelial function after short term oral l-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials
  6. Inflammation in atherosclerosis: Imaging, biomarkers and novel therapeutic opportunities
  7. Acute L-Arginine supplementation does not increase nitric oxide production in healthy subjects
  8. House, L.M., et al. Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function. Cardiovascular Diabetology. 2015.
  9. Tangadi, D., Bhutani, N., & Bhavsar, P. (2020). Coronary Artery Disease, Nitric Oxide, Insulin Resistance, Polymorphism, RFLP.
  10. Wang, Y., Cheng, K., Lam, K., Wu, D., Wang, Y., Huang, Y., Vanhoutte, P., Sweeney, G., Li, Y., & Xu, A. (2011). APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice. Diabetes, 60, 3044–3054.
  11. House, L. M., Morris, R. T., Barnes, T. M., Lantier, L., Cyphert, T. J., McGuinness, O., & Otero, Y. (2015). Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance. Cardiovascular Diabetology
  12. Sprague AH, Khalil RA. "Inflammatory cytokines in vascular dysfunction." Biochem Pharmacol. 2009
  13. Steyers CM, Miller FJ. "Endothelial dysfunction in chronic inflammatory diseases." Int J Mol Sci. 2014
  14. Gimbrone MA, García-Cardeña G. "Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis." Circ Res. 2016
  15. Torregrossa, A.C., Aranke, M., & Bryan, N.S. (2011). "Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly." Journal of Geriatric Cardiology, 8(4), 230-242.
  16. Taddei, S., et al. (2000). "Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes." Circulation, 101, 2896-2901.
  17. Scalera, F., Closs, E. I., Flick, E., Martens-Lobenhoffer, J., Boissel, J. P., Lendeckel, U., Heimburg, A., & Bode-Böger, S. M. (2009). Paradoxical effect of L-arginine: Acceleration of endothelial cell senescence. Biochemical and Biophysical Research Communications, 386(4), 650–655.
The Evolution from Health Care to Advanced, Award-Winning Health Solutions for Generation X and Baby Boomers
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† Disclaimer: These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Use only as directed. Consult your healthcare provider before using supplements or providing supplements to children under the age of 18. The information provided herein is intended for your general knowledge only and is not intended to be, nor is it, medical